The gold standard for definite diagnosis of NS is the identification of pathologic variants in SPINK5 gene, which are found in both patients [1,12].Allergic conditions are other common manifestations of NS [2,6]. Even though our patients showed extremely high levels of total IgE, only case 2 had an allergic problem, which was multiple food allergies. The gene discussed is SPINK5; the disease is food allergy.