With pathology showing poorly differentiated adenocarcinoma likely of prostatic origin and a high Gleason score of 9 (4+5), surgical treatment with nephroureterectomy followed by medical management of hormonal-related therapy and steroids (LHrH agonist, abiraterone, prednisone) was given, and the patient has had well-controlled PSA levels (<0.04 ng/mL) for the past two years with stable renal function. This evidence concerns the gene GNRH1 and adenocarcinoma.