Tumor‐associated stroma is composed of many types of cells, including adipocytes, mesenchymal stem cell, fibroblasts, and immune cells, as well as some ECM proteins, such as FN and tenascin C.59, 60In previous reports, increased FN expression in primary tumors plays an important role in poor patient survival.61, 62. The gene discussed is FN1; the disease is neoplasm.