Hemizygous TgM83+/− (B6;C3‐Tg(Prnp‐SNCA*A53T)83Vle/J) mice overexpress mutant human A53T alpha‐synuclein and are widely used in PD and synucleinopathy research due to the significantly elevated amounts of aggregated alpha‐synuclein in their brain upon infection with pre‐formed alpha‐synuclein fibrils. Here, PRNP is linked to Parkinson disease.