(3) reported haploinsufficiency of TCF12 in 13 families with anosmic HH (12 autosomal dominant, one autosomal recessive) in 2020, and also reevaluated five TCF12 variants in a Spanish cohort with craniosynostosis and identified one with pubertal failure and anosmia (18). This evidence concerns the gene TCF12 and craniosynostosis.