TCF12 and central nervous system cancer: It has been shown that overexpression of TCF12 causes a more aggressive course and negatively affects prognosis by increasing cell proliferation, migration, and invasion, and inhibits apoptosis in many cancer types such as hepatocellular carcinoma, T-cell lymphoma, ovarian carcinoma, glioma, colorectal carcinoma (9, 10, 32–35).