After grouping according to whether the subjects were diabetic, we also found that compared to the non-diabetic group, diabetic subjects at baseline had significantly higher proportions of hypertension, CHD, heart failure with reduced ejection fraction (LVEF < 50%), underwent SGLT-2 treatment, NYHA class IV, and higher levels of SBP, ABG, HbA1c, WBC, RBC, PLT, ALB, GGT, Cr, and TG, as well as lower levels of LVEF and HDL-C. The gene discussed is SLC5A2; the disease is heart failure.