In our study, we identified six plasma proteins, including PTGES2, RNASET2, SF3B4, STX8, ENO2, and HS3ST3B1 (previously unknown in eQTL and mQTL, except for RNASET2), that were significantly associated with BCC after FDR correction in the UKB-PPP and deCODE studies (FDR<0.05). This evidence concerns the gene STX8 and skin basal cell carcinoma.