Further VUSs have been detected in the PIEZO1 gene, encoding the piezo-type mechanosensitive ion channel component 1, which was shown to be a key modulator of abnormal platelet activation and thrombosis under hypertension [41], and GLCE gene, encoding the D-glucuronyl C5-epimerase, involved in heparan sulfate/heparin biosynthesis [42]. Here, GLCE is linked to hypertensive disorder.