APP and familial Alzheimer disease: Here, we have used two mouse models, one expressing the human APP allele (Apphu) and another expressing the human APP sequence with three variants that promote abnormal Aβ accumulation associated with early onset familial Alzheimer’s disease (AppNL-G-F), to characterize relationships between NAB61+ Aβ oligomers or 6C3+ Aβ plaques and glial activation.