Furthermore, the proteotoxic aggregates of the A53T mutant version of α-synuclein, which is associated with an autosomal dominant form of Parkinson’s disease, were successfully degraded by reduced ER acetylation only when α-synuclein was forced to insert into the ER lumen by adding a signal peptide to its N-terminus.10 In essence, ATase inhibitors appear to be selective for ER/secretory pathway proteotoxicity. Here, PPAT is linked to Parkinson disease.