The ‘Typical AD Early Tau’, ‘Typical AD Late Tau’, ‘Cortical’ and ‘Cognitive’ subtypes were replicated when running missing-data SuStaIn in amyloid-positive individuals only, whilst the ‘Subcortical’, ‘Cortical’ and ‘Cognitive’ subtypes were also found in amyloid-negative individuals. The gene discussed is MAPT; the disease is Alzheimer disease.