MAPT and early-onset autosomal dominant Alzheimer disease: Established Alzheimer’s disease biomarkers include CSF10 and PET imaging of amyloid and tau accumulation;11,12 MRI of regional brain atrophy;13 and cognitive test scores.14 As each of these modalities provide different information and are likely dynamic at different stages,15 integrating information from a range of different disease biomarkers is key to building a complete picture of Alzheimer’s disease.16,17