M-MDSCs are classified as CD11b+Ly6G−Ly6Chi and PMN-MDSCs are defined as CD11b+Ly6G+Ly6Clow, both of which are implicated in various aspects of immune regulation, from pregnancy to diseases that involve chronic inflammation, including infections, autoimmune diseases, and other pathologies (Bronte et al., 2016; Köstlin et al., 2016; Goldmann et al., 2017). The gene discussed is ITGAM; the disease is autoimmune disease.