TLR2 and paracoccidioidomycosis: Considering that TLR2 absence led to a reduction in MDSCs expressing nitrotyrosine and that nitrotyrosine expression by MDSCs is associated with severe paracoccidioidomycosis in mice (Preite et al., 2023), it would be intuitive to assume that blocking TLR2 could contribute to reducing the deleterious effects mediated by nitrotyrosine+ MDSCs in PCM.