The multivariate analysis identified HTN (aOR, 27.481; 95% CI, 7.928 to 95.256; p < 0.001), a history of PE (aOR, 5.415; 95% CI, 1.396 to 21.002; p = 0.015), associated APS (aOR, 3.962; 95% CI, 1.558 to 10.072; p = 0.004), proteinuria in the first trimester (aOR, 5.027; 95% CI, 2.428 to 10.407; p < 0.001), and low serum C4 in the first trimester (aOR, 2.711; 95% CI, 1.174 to 6.261; p = 0.02) as independent risk factors for PE. Here, C4A is linked to hypertensive disorder.