BRSK2 and cardiovascular disorder: In fact, BRSK2 is associated with neuronal development and glucose regulation, likely justifying the increased risk for diabetes and cardiovascular disease in PTSD,43 whereas ADCYAP methylation is negatively correlated with a major regulator of the hypothalamus–pituitary–adrenal (HPA) axis and stress, and it has already been associated with PTSD severity.44 Although based on a small sample size (n = 24 PTSD raped women vs. n = 24 non-PTSD raped women), the authors observed hypomethylation status of both genes in those victims who developed PTSD symptoms.