Binary logistic regression analysis for depression (as a dependent variable) with multiple independent variables including gender, nationality, pharmacological treatment for diabetes and duration of diabetes mellitus showed that males were at a higher risk of depression (AOR= 1.98, 95% CI 1.25-3.15, p = 0.004), while being Qatari and treatment for diabetes with insulin were at lower risk for depression development (AOR = 0.56, 95% CI 0.34-0.90, p = 0.017, 0.49, 95% CI 0.30-0.78 p =0.003 respectively). The gene discussed is INS; the disease is major depressive disorder.