Downregulation of CRL4CUL4A/DDB1, promotes mitophagy by regulating the PINK1/Parkin axis, DRP1 dephosphorylation at Ser637, and the interplay between DRP1 and voltage-dependent anion channel 1 (VDAC1), ultimately driving mitochondrial fission and mitophagy in chemotherapy-resistant ovarian tumor cells (Meng et al., 2022). This evidence concerns the gene DNM1L and ovarian neoplasm.