Similarly, the deregulation of the above PQC factors has been linked, for instance, to premature senescence (STUB1) [100], neurodegenerative motor neuron disease (UBA1) [101], myofibrillar myopathy, cardiomyopathy and congenital cataracts (αB-crystallin) [102]. Here, UBA1 is linked to early-onset non-syndromic cataract.