CD4 and neoplasm: Interestingly, although MHC-II expression did not statistically correlate with the total immune cell infiltrate in tumor islands (p=0.097), it strongly correlated with a high presence of both CD4+ TH (p=0.047) and CD8+ CTL (p=0.012), but not with CD68+ cells (p=0.099) (Table 3, Figure 1).