The results reveal that the article titled “Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells” (5) published in Nature in 2021, leads significantly with an annual average citation count of 71, followed by the article published in Clinical Research, titled “Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade” (28) which holds the second position with an annual average citation count of 55.4. The gene discussed is CD274; the disease is non-small cell lung carcinoma.