Interestingly, among the top five enriched hallmarks in GSEA of ICAM1 correlating genes in the TCGA AML database, we identified the IL6_JAK_STAT3_SIGNALING hallmark pointing towards a correlation of ICAM1 with not only STAT3 expression, but also STAT3 activity (Supplementary Figure S5C). The gene discussed is IL6; the disease is acute myeloid leukemia.