Inactivation of endogenous VEGF expression leads to decreased angiogenesis, further emphasizing the importance of VEGF in this process.19Previous research by Kryger et al revealed that administration of exogenous VEGF via various routes of administration protected against hypoxic damage in random skin flaps.20PRP also increases levels of PDGF, TGF-β, IGF, EGF, and VEGF, thereby promoting enhanced angiogenesis, endothelial cell migration, and acceleration of tissue regeneration, ultimately improving overall wound healing outcomes in diabetes.11 This evidence concerns the gene IGF1 and diabetes mellitus.