NOTCH1 and diabetic foot: Cheng et al showed how subcutaneous injection of PRP increased angiogenesis and improved fur growth in rats.21Furthermore, it was found that PRP administration alone or in combination with adipose mesenchymal stem cells and endothelial progenitor cells accelerated wound healing in diabetic mice by augmenting angiogenesis through the Notch1 pathway.22Moreover, the use of PRP in diabetic foot ulcers also reduces the rate of wound infection.23