As anticipated, HMGCR significantly increased the risk of CHD in both the IVW method (OR [95%] = 1.62 [1.36–1.93], P = 8.29 × 10−8) and weighted median method (OR [95%] = 1.61 [1.27–2.04], P = 7.09 × 10−5) (Figure 2). Here, HMGCR is linked to coronary artery disorder.