FAK is canonically known to promote cell motility at focal adhesions (Mitra et al., 2005) and Pyk2 signaling supports formation of invadopodia, protease-containing cell projections that create stromal escape conduits for tumor cells (Genna and Gil-Henn, 2018; Genna et al., 2018; Mierke et al., 2017). The gene discussed is PTK2B; the disease is neoplasm.