PTK2 and neoplasm: In blood vessel endothelial cells (ECs) of adult mice, conditional EC FAK loss supported normal tumor growth and angiogenesis (Weis et al., 2008), whereas in a related EC FAK knockout model, FAK loss resulted in partial inhibitory effects on tumor size and neovascularization, albeit using less-aggressive implanted tumor cells (Tavora et al., 2010).