In general, although early FAK PROTAC compound development identified molecules that inhibit tumor cell motility and invasion at nanomolar concentrations (Cromm et al., 2018), other FAK PROTAC compounds showed that FAK knockdown had no effect on tumor cell growth in vitro (Gao et al., 2020a; Popow et al., 2019). The gene discussed is PTK2; the disease is neoplasm.