CXCR2 and neoplasm: CXCL5 binds to its receptor, C-X-C motif chemokine receptor 2 (CXCR2), and the CXCL5/CXCR2 axis directly promotes angiogenesis, tumor growth, and metastasis via the ERK/Snail pathway or the AKT/GSK3β/β-catenin pathway [12–15].