It can be concluded that under PD pathologic conditions, activation of the NF-κB signaling pathway in microglia promotes the secretion of inflammatory chemokines, such as RANTES and eotaxin, thus increasing the infiltration of CD8+ T cells into the SN of PD and enhancing the cytotoxic response to dopaminergic neurons [33]. This evidence concerns the gene CCL5 and Parkinson disease.