MAPT and Alzheimer disease: Although the available evidence remained inconclusive regarding the role APOEε4 plays in modulating the effect of HT on AD-related pathologies, results from voxel-based analyses in this study revealed that among the post-menopausal HT + females, APOEε4 carriers showed similar level of Aβ-PET and tau-PET as APOEε4 non-carriers.