However, when comparing UCHLs expression in RCC samples of different stages, we found that UCHL1 and UCHL5 were up-regulated in late stage of RCC or RCC with higher malignity, suggesting that positive screening of UCHL1/5 may be used as an indicator of poor prognosis of RCC (TCGA database). The gene discussed is UCHL5; the disease is renal cell adenocarcinoma.