As for research genes, the most frequent findings were VUS in CSMD1, detected in13 patients (6%), but their clinical features did not differ significantly from negative controls (Table 1) and resembled idiopathic PD, with onset around 60 years of age and rare occurrence of dystonia and RBD (8%); there was a positive family history in 62% but segregation study in one family did not support a pathogenic role of the CSMD1 variant found. The gene discussed is CSMD1; the disease is Dystonia.