Notably, elevated YBX1 activity was observed in Macro_FOLR2 + APOE + , Macro_FOLR2 + APOE-, Macro_APOC1 + IFI27 + , cDC(CD1C), Macro_OLFML3, and cDC_CLEC9A in responders with CRC, while BCL3 activity was increased in Mono_CD14, Macro_NLRP3, Mono_INHBA, Macro_OLFML3, and Macro_ISG15 in non-responders with CRC. Here, APOE is linked to colorectal carcinoma.