Several cancer types exhibited significant decreases in the proportions of Macro_ISG15 and Mono_INHBA after treatment, while Macro_FOLR2 − APOE + , Macro_APOC1 + IFI27 + , Macro_LYVE1, and Macro_OLFML3 showed significant increases in the Post group (Fig. 1d, e and Supplementary Fig. 3a-b). This evidence concerns the gene APOE and cancer.