DMBT1 and neoplasm: Goeppert and colleagues did not observe differences in DMBT1 expression in iCCA compared to normal biliary tissue while they identified a significant decrease of DMBT1 expression in iCCA compared to biliary intraepithelial neoplasia (BilIN) 3 suggesting a tumor suppressing role of DMBT1 in early cholangiocarcinogenesis (Goeppert et al. 2017).