To examine if patient-derived Y402H RPE cells with lysosomal dysfunction could be rescued by targeting AKT2 and trehalose, we treated iPSC-derived RPE cells from AMD patients from CFH (Y/Y) and (H/H) donors (Supplementary Table 3) with or without trehalose or the AKT2 inhibitor. Here, AKT2 is linked to age-related macular degeneration.