AKT2 and age-related macular degeneration: To assess the contribution of lysosomal dysfunction to the AMD phenotype in the RPE of Akt2 KI mice, we examined the expression of a group of genes in these cells, known as the Coordinated Lysosomal Expression and Regulation (CLEAR) network genes, which are associated with lysosomal biogenesis acidification and the autophagy pathway7.