Given the central role of AKT2 in maintaining these cellular processes, the present study was undertaken to establish the role of altered AKT2-dependent signaling on lysosomal function and autophagy in the RPE that contributes to AMD pathology and the impact of AKT2 signaling in the RPE on the AMD phenotype and the influence of the CFH Y402H variant on lysosomal function. Here, AKT2 is linked to age-related macular degeneration.