Further in lung cancer tissues, through scRNA analysis at “IMMUcan SingleCell RNAseq-Database” of lung cancer, for the first time, we proved the specificity of COL1A1, COL1A2, and FAP, all of three are highly enriched in subgroup of CAF (Fig. 2D), the cluster of which was circled. Here, COL1A1 is linked to lung cancer.