Except few MDS subtypes could be clearly defined by gene mutations (i.e. mutations in SF3B1 induces the MDS-RS subtype), most of the MDS have no clear diagnosis criteria since they share numerous mutations in a panel of common genes and even have quite similar symptoms as other myeloid abnormalities (i.e. AML, chronic myelomonocytic leukemia CMML, or myeloproliferative neoplasm MPN), or autoinflammatory diseases (i.e. vacuoles E1 enzyme X-linked autoinflammatory somatic, VEXAS) [4, 9, 28, 36]. This evidence concerns the gene SF3B1 and chronic myelomonocytic leukemia.