Additionally, a strong positive correlation was found between IL-17 concentration and IgE content, and IL-17 was one of the main reasons for the increase in serum IgE content of AR patients, indicating that IL-4 and IL-17 are involved in the regulation of IgE production during the pathogenesis of AR, thereby inducing the occurrence of allergic reactions. The gene discussed is IGHE; the disease is allergic disease.