We observed that patients with STAG2 mutations were older than patients with mutations in other cohesin genes at time of AML diagnosis (70 vs. 64 vs. 64/57/50 years, p < 0.001, Supplementary Fig. 3D) but not at time of MDS diagnosis (Supplementary Fig. 3E). Here, STAG2 is linked to acute myeloid leukemia.