SLFN11 and colorectal cancer: Similar to the results in cell models, low SLFN11 expression was associated with poor response to irinotecan in colorectal cancer patients (Fig. S8E–F), the response rates being high in colorectal cancers with high SLFN11 and low ABCG2 expression and low in colorectal cancers with low SLFN11 and high ABCG2 expression (Fig. S8G).