The observed lower prevalence of STK11 and KEAP1 alterations in the KRAS-altered EAS and AMR as compared to the other ancestry groups may also stem from ancestry-specific germline variations, as both NAT and Hispanic/Latino NSCLC populations have been shown to exhibit a relatively lower prevalence of STK11 and KEAP1 alterations compared to EUR and Non-Hispanic White patients45,46. This evidence concerns the gene KRAS and non-small cell lung carcinoma.