EGFR and SATB2 associated disorder: MDM2 alterations frequently co-occurred with EGFR alterations across ancestries (OR > 2, p < 10−5 for all groups except SAS; Fig. 3c, Supplementary Data 11); notably, MDM2 alterations were more frequent in EGFR-altered EAS as compared to the EGFR-altered EUR subgroup (12.3% vs 8.3%, p < 10−5) (Fig. 3b, Supplementary Data 10), perhaps in part due to the higher overall prevalence of MDM2 alterations in the EAS population (Supplementary Fig 1, Supplementary Data 1).