MDM2 alterations frequently co-occurred with EGFR alterations across ancestries (OR > 2, p < 10−5 for all groups except SAS; Fig. 3c, Supplementary Data 11); notably, MDM2 alterations were more frequent in EGFR-altered EAS as compared to the EGFR-altered EUR subgroup (12.3% vs 8.3%, p < 10−5) (Fig. 3b, Supplementary Data 10), perhaps in part due to the higher overall prevalence of MDM2 alterations in the EAS population (Supplementary Fig 1, Supplementary Data 1). This evidence concerns the gene MDM2 and SATB2 associated disorder.