Moreover, although unlike PD-L1 levels, the predictive value of TMB for the use of ICI remains debated, the high mutational burden has been shown as a poor prognostic factor, and EAS non-Sq NSCLC have been shown to harbor more stable genomes as compared to EUR non-Sq NSCLC42,53–55. This evidence concerns the gene CD274 and non-small cell lung carcinoma.