Toll-like receptor 4 (TLR4)/tumor necrosis factor receptor-associated factor 6 (TRAF6)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome signaling pathway is one of the most important inflammatory pathways, which integrates inflammation and fibrosis in diabetes-induced renal injury pathogenesis [12, 13]. Here, TLR4 is linked to diabetes mellitus.