In esophageal cancer, the expression of METTL3, IGF2BP3, and WTAP is increased, and all of them have been confirmed to be related to the extent of tumor invasion, lymph node and adjacent organ invasion, distant metastasis, and other criteria used to identify the stage, and by observing the m6A methylation expression level to help the early diagnosis of tumors and determine the prognosis of tumors [265–267]. The gene discussed is WTAP; the disease is neoplasm.