In addition, increased LA in TME upregulated METTL3 in tumor-infiltrating myeloid cells (TIMs) and enhanced Janus kinase 1(JAK1) protein translation efficiency and subsequent transcription activator 3(STAT3) phosphorylation via the m6A-YTHDF1 axis in CRC [126]. This evidence concerns the gene METTL3 and neoplasm.