Further examples where tissue-specificity signal was clarified in hotspots include major OGs such as KRAS and NRAS, which were implicated in melanoma, multiple myeloma, kidney for KRAS, or uterus, lung, stomach and other cancers, for NRAS (Fig. 2c, Supplementary Fig. S4a); see additional discussion and context for these examples in Supplementary Note 1. Here, NRAS is linked to AL amyloidosis.