EGFR and breast cancer: Examples of thusly identified driver genes are shown in Fig. 2c, and here we highlight the EGFR gene in the luminal subtypes of breast cancer (log2 fold-enrichment = 5.72 across all three copy number states; p = 2.5 × 10−4, FDR = 0.03, Fig. 2f), and ERBB2 in several cancer types (FDR ≤ 5%, at Fig. 2f).