In particular, the TSGs NF2 in LIHC, TP53 in THCA, VHL in UCEC, B2M in SKCM, PTEN in THCA, STK11 in SKCM and COREAD (FDR ≤ 25%) and other noncognate or uncertain gene-tumor pairs were not showing significant selection in diploid state, but did show selection in tumors with deletion in the same gene (Fig. 3b, d, Supplementary Fig. S6a, b). The gene discussed is B2M; the disease is neoplasm.