The upregulation of expression of the lipocalin Neural Lazarillo (NLaz, mammalian ApoD) through the Jun-N-terminal kinase (JNK) pathway is proposed to be a part of the cellular stress-response pathway that contributes to the development of insulin resistance in HSD – indeed, NLaz is necessary and sufficient for this effect in the fly10. Here, MAPK8 is linked to Insulin resistance.