To further assess the role of Ca2+ influx-induced [Ca2+]ex drop in psoriasis pathology, we established psoriasis model by applying IMQ cream to the ear using R26-LSL-CEPIAexternal;Itgal-LSL-Clover;Itgb2-LSL-mRuby2;CD4-Cre mice and injected with SKF96365 or DMSO daily for 7 days (Fig. 9d). This evidence concerns the gene CD4 and psoriasis.