The hijacked enhancers on chromosome 8 in ZR751 exhibit H3K27ac enrichment in the breast cancer cell line T47D without the translocation (Figure S4A), but little enrichment in the B-cell lymphoma line REC1 in which CCND1 hijacks enhancers from chromosome 14 (Fig. 3C). Here, CCND1 is linked to B-cell non-Hodgkin lymphoma.