For example, in pancreatic ductal adenocarcinoma, the knockdown of CCCTC-binding factor (CTCF) resulted in the downregulation of specific biomarkers of M2-like tumor-associated macrophages (TAMs), such as Mrc1 and CD163, reducing invasion and metastasis capabilities [61]. This evidence concerns the gene CTCF and pancreatic ductal adenocarcinoma.