The verification results of USP13 expression and TAK1 activation were present in Fig. 7G and H. We observed that though the body weights of HFD WT + DMSO, HFD KO + DMSO and HFD KO + Oxozeaenol groups were similar (Fig. 7A), the glucose and lipid metabolism disorders were alleviated when suppressing the TAK1 activation in USP13-KO mice (Fig. 7B–F). Here, USP13 is linked to Disorder of lipid metabolism.