PRDM16 and rotator cuff syndrome: PRDM16, a PR-domain-containing protein, drives the molecular phenotype of brown fat cells, and knockdown of this gene ablates the genetic program of brown fat.11,17,31 Interestingly, FAPs contain receptors for PRDM16, which when bound, causes differentiation into BAT-FAPs.49 Receptors for this protein are also located in intramuscular white adipose tissue and leads to the conversion of white fat into brown fat.9 This could potentially improve outcomes in rotator cuff tear patients, as fatty infiltration and muscle quality are significant predictors for successful clinical outcomes.50