This result clearly demonstrated elevated NEAT1_2 is necessary and sufficient for driving GBM cell migration, regardless of diminished NEAT1_1. The fact that the regulation of cell migration GO pathway is enriched of upregulated DEGs in NEAT1 ΔPAS GBM cells and the reversal of DEGs indicated in cell migration by ASO KD of NEAT1_2 provides a novel molecular mechanism that further supports the oncogenic roles of NEAT1_2 in driving glioma cell migration and likely metastasis. The gene discussed is NEAT1; the disease is glioma.