Indeed, elimination of QKI-5, by either transient siRNA KD of QKI-5 in multiple GBM cell lines (Fig. S4) or CRISPR-Cas9 deletion of the QKI-5–specific exon 7c in the U373 GBM cell line (Fig. 4) significantly reduces endogenous NEAT1_1 but reciprocally elevates NEAT1_2. Moreover, mutagenesis of the QREs clearly demonstrates the suppression of cleavage at the NEAT1 PAS in a reporter transcript (Fig. 5). The gene discussed is NEAT1; the disease is glioblastoma.