We identified QKI recognition element (QRE) sequences located upstream of the human NEAT1 PAS (Fig. 4A), which are consensus RNA motifs containing ACUAAY-(1–20 nt)-UAAY for the binding of the glial RBP QKI encoded by a glioma risk gene (62, 63, 64, 65, 66). Here, NEAT1 is linked to central nervous system cancer.