atRA has also been reported to reduce hepatic lipid accumulation in liver steatosis model animals by repressing peroxisome proliferator-activated receptor gamma (PPARγ) and to induce lipolysis by a PPARβ/δ-mediated increase in the levels of hormone-sensitive lipase (HSL) in adipocytes (28, 29). The gene discussed is LIPE; the disease is fatty liver disease.