PTEN and cancer: In cases without PTEN and TP53 alterations, the association between RASAL1 alterations and pAKT still showed significance or a trend in some cancer types, such as BRCA (P_pT308 = 0.14, P_pS473 = 0.76) and lung adenocarcinoma (P_pT308 = 0.013, P_pS473 = 0.002) (Fig. 2B).