In low grade glioma (LGG), the RASAL1_PTEN_noTP53 group showed the highest AKT_pT308 level, higher than any of the other three groups (P = 0.0032, 0.0036, and 0.0026, Fig. 3A), with no difference between the only RASAL1‐ or only PTEN‐altered group and the noRASAL1_noPTEN_noTP53 group (P = 0.36 and 0.083). Here, PTEN is linked to glioma.