Analysis of the reverse phase protein array (RPPA) data revealed that cancers with RASAL1 alterations showed higher levels of AKT phosphorylation in the PI3K pathway (pAKT, pS473 and pT308) than cancers without RASAL1 alterations in several cancers (Fig. 2A), such as breast cancer (BRCA) (P_pT308 = 0.0098, P_pS473 = 0.24, two‐sided Student's t‐test), prostate adenocarcinoma (P_pT308 = 0.13, P_pS473 = 0.022), and thymoma (P_pT308 = 0.0056, P_pS473 = 0.0098). This evidence concerns the gene RASAL1 and thymoma.