Some deleterious mutations in RASAL1 were reported in follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC) with in vitro confirmation of their oncogenic consequences, identifying RASAL1 for the first time as a tumor suppressor gene in a human cancer (thyroid cancer) [8, 18]. The gene discussed is RASAL1; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.