These results illustrated that the efficacy of an ICI alone would be far inferior to that of an ICI combined with chemotherapy, while another study contended that the relevant theoretical concept underlying such findings may be that radiotherapy, chemotherapy, and targeted therapies may affect the function of immune cells in the tumor microenvironment, leading to the better therapeutic efficacy that is obtained via combination with anti‐PD‐1/PD‐L1 ICIs.32, 33, 34. This evidence concerns the gene CD274 and neoplasm.